How CombiPatch® Works

COMBIPATCH has three layers and steadily releases continuous amounts of both estrogen and progestin through your skin. You place COMBIPATCH on your lower abdomen and change it twice per week, based on your own dosing schedule.

Innovative Technology

COMBIPATCH was created using the patented Delivery Optimized Thermodynamics (DOT) Matrix delivery system. DOT Matrix technology allows a continuous release of hormones to your skin that goes directly into your bloodstream. This helps to treat moderate to severe hot flashes, night sweats, and vaginal dryness associated with menopause.

You and your healthcare provider should talk regularly about whether you still need treatment with COMBIPATCH to control these problems. If you use COMBIPATCH only to treat menopausal changes in and around your vagina, talk with your healthcare provider about whether a topical vaginal product would be better for you.

Effective Combination Hormone Therapy

COMBIPATCH provides effective hormone levels with smaller daily doses as compared to oral therapy. This does not mean that COMBIPATCH is safer or more effective than hormone therapy pills. When taken orally, estrogen has to first pass through the stomach and then be metabolized by the liver before reaching the bloodstream. During this process, a lot of estrogen is broken down and eliminated. So in order for your body to receive enough estrogen to relieve your symptoms, the dose in a pill has to be higher than the dose used in a transdermal patch, which avoids the initial metabolism by the liver by delivering hormones directly to the bloodstream. COMBIPATCH provides a continuous release of hormones to your skin and goes directly into your bloodstream. That means you can get effective symptom relief with a smaller daily dose of hormones than with HT pills.*

*This does not mean that COMBIPATCH is safer or more effective than hormone therapy (HT) pills or other hormone therapies.

COMBIPATCH achieves estrogen levels in your blood similar to what you would see in the early phase of your usual menstrual cycle during your premenopausal years. These levels are achieved within 12 to 24 hours after applying COMBIPATCH.

Find out about COMBIPATCH dosing options.