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    Questions to Ask Your Doctor

    Talk to your doctor about treating your moderate to severe symptoms associated with menopause.
    Together, you and your doctor can decide what the best treatment option is. It can be helpful to plan ahead for your doctor’s visit by having a list of questions prepared. Print out this list and bring it with you to your appointment.

     

    Questions about Menopause

    • What should I expect?
    • What causes symptoms associated with menopause, such as hot flashes, night sweats, and vaginal atrophy and dryness?
    • Would a healthier lifestyle, such as proper diet, exercise, sleep, or reducing stress, help reduce my symptoms?
    • When should I consider hormone therapy for my menopause symptoms?
    • Why is it possible to experience bleeding if I’m in menopause?
    • Where can I get more information about menopause?

    Questions about Treatment Options

    • What are the risks and benefits of hormone therapy?
    • If I choose hormone therapy, will I be on it for the rest of my life?
    • What are the benefits of transdermal hormone therapy?
    • Am I a candidate for transdermal hormone therapy?

    Questions about COMBIPATCH®

    • Is COMBIPATCH right for me?
    • How is COMBIPATCH different from hormone therapy pills?
    • Which COMBIPATCH dosing regimen is right for me?
    • How do I apply COMBIPATCH?
    • How long will it take to feel a difference in my symptoms?
    • What are the side effects of COMBIPATCH?
    • What bleeding pattern should I expect?
    • What do I do if the patch falls off?
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    The recommended storage conditions for COMBIPATCH have been updated.

    Please click here to see full announcement >

    The recommended storage conditions for COMBIPATCH have been updated.

    Please click here to see full announcement >

    The site you are about to enter is intended specifically for U.S. healthcare professionals

    Click continue if you are a U.S. healthcare professional

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    Leaving the COMBIPATCH® Web Site

    You are now leaving the CombiPatch Web Site and moving to an external Web site independently operated and not managed by Noven Pharmaceuticals. Noven assumes no responsibility for the content of the site.

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    Pay as little as $25 on each COMBIPATCH® prescription*†

    Copay Savings Offer

    Eligible patients pay as little as $25 on each prescription for up to 6

     

    COMBIPATCH® (estradiol/norethindrone acetate transdermal system) prescriptions.*†

    To get started, just follow these steps:

    Click on the savings offer button to download your offer.

     

    1. Take the printout to your doctor.
    2. If you and your doctor have decided that CombiPatch® may be right for you, ask your doctor for a prescription for COMBIPATCH®.
    3. Take your COMBIPATCH® prescription, along with your savings card printout,to a pharmacy to fill your prescription and to start saving!
    Download and print your offer

    *On copays up to $80, pay as little as $25 for a 1-month supply. On copays in excess of $80, or non-covered prescriptions, you may qualify for up to $55 in savings for a 1-month supply.

    †For eligible patients only. Restrictions apply. See offer for the full terms and conditions

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    The site you are about to enter is intended specifically for U.S. healthcare professionals

    Click continue if you are a U.S. healthcare professional

    Continue
    July 2022

    IMPORTANT PRESCRIBING INFORMATION

    Subject: New Packaging Reflecting Updated Storage Conditions for CombiPatch®
    (estradiol/ norethindrone acetate transdermal system)
    Dear Health Care Provider,
     
    In December 2021, Noven Pharmaceuticals Inc., announced a change in the storage conditions for CombiPatch® (estradiol/norethindrone acetate transdermal system) 0.05/0.14 mg/day and 0.05/0.25 mg/day, approved by the U.S Food and Drug Administration (FDA).
     
    The new storage condition only allows to “store CombiPatch in the refrigerator at 2°C to 8°C (36°F to 46°)”. Previous CombiPatch storage conditions allowed for the product to be stored as follows: “Prior to dispensing to the patient, store refrigerated 2°C to 8°C (36°F to 46°F). After dispensing to the patient, CombiPatch can be stored at room temperature between 20°C to 25°C (66°F to 77°F) for up to 6 months”.
     
    The change in the storage condition for CombiPatch from up to 6 months at room temperature between 20°C to 25°C (66°F to 77°F) to fully refrigerated between 2°C to 8°C (36°F to 46°F), is not due to a product change. Recent analyses of test results showed that storage of CombiPatch in refrigerated conditions of 2°C to 8°C (36°F to 46°F) lead to improvement of product adhesion.
     
    Please note that the earliest patients will see changes to the outer packaging of CombiPatch reflecting these storage condition changes is September 2022. We advise you to please continue to proactively inform any patients receiving CombiPatch of its updated storage conditions.
     
    Prescriber Action:
    Continue to counsel all patients about the risks and benefits of CombiPatch, including:
    • The new storage requirements to ensure optimal adhesion of the product.
    • Patients should store all sealed CombiPatch in the refrigerator (2°C to 8°C (36°F to 46°F)) until they are ready to apply the transdermal system. Allow the transdermal system to reach room temperature before application.
     
    Note: All commercially available CombiPatch stored at previous storage recommendations are still safe and effective for use and, can continue to be used by patients.
     
    Please ensure your staff and any provider in your institution who may be involved in the handling, storage and dispensing of CombiPatch, receives a copy of this letter and specifically reviews the updated storage conditions
     
    Reporting Adverse Events
    Noven encourages the reporting of adverse events expeditiously. To report adverse events, product quality complaints or to request medical information related to CombiPatch please contact Noven Medical Information at (800) 455-8070 (9 a.m- 5 p.m EST, Mon-Fri).

    Adverse events or quality problems experienced with the use of this product may also be reported to the FDA MedWatch Adverse Event Reporting program either online, by regular mail, telephone, or fax.
     

     

    This letter is not intended as a complete description of the benefits and risks related to the use of CombiPatch. Please refer to the full prescribing information including patient information available on www.combipatch.com. For additional information, please call Noven at 1-800- 455-8070.
     
    We will continue to work diligently to provide a consistent supply of CombiPatch. We appreciate your assistance in this matter and apologize for any inconvenience.
     
    Sincerely,
     
    Joel S. Lippman, MD
    COO & CMO